What Causes Deep Gray Matter Atrophy in Multiple Sclerosis?
نویسندگان
چکیده
منابع مشابه
White-matter lesions drive deep gray-matter atrophy in early multiple sclerosis: support from structural MRI.
BACKGROUND In MS, the relationship between lesions within cerebral white matter (WM) and atrophy within deep gray matter (GM) is unclear. OBJECTIVE To investigate the spatial relationship between WM lesions and deep GM atrophy. METHODS We performed a cross-sectional structural magnetic resonance imaging (MRI) study (3 Tesla) in 249 patients with clinically-isolated syndrome or relapsing-rem...
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OBJECTIVE To determine gray matter (GM) atrophy rates in multiple sclerosis (MS) patients at all stages of disease, and to identify predictors and clinical correlates of GM atrophy. METHODS MS patients and healthy control subjects were observed over 4 years with standardized magnetic resonance imaging (MRI) and neurological examinations. Whole-brain, GM, and white matter atrophy rates were ca...
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Introduction: We have applied tensor based morphometry (TBM) method to study the atrophy and shape changes of deep gray matter (DGM) structures in 88 Relapsing-Remitting Multiple Sclerosis (RRMS) patients. To improve the accuracy and robustness of morphometry measurement, an unbiased template was constructed from 20 normal brains for group comparison. A symmetric inverse consistent nonlinear re...
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Gray matter (GM) lesions are recognized as important components of the pathology of multiple sclerosis (MS), and involvement of the deep gray matter (DGM) is suggested by magnetic resonance imaging. The aims of this study were to determine the frequency and distribution of lesions and characterize the inflammatory and neurodegenerative changes in DGM of MS patients. Histochemistry, immunohistoc...
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BACKGROUND AND PURPOSE Deep gray matter iron accumulation is increasingly recognized in association with multiple sclerosis and can be measured in vivo with MR imaging. The cognitive implications of this pathology are not well-understood, especially vis-à-vis deep gray matter atrophy. Our aim was to investigate the relationships between cognition and deep gray matter iron in MS by using 2 MR im...
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ژورنال
عنوان ژورنال: American Journal of Neuroradiology
سال: 2018
ISSN: 0195-6108,1936-959X
DOI: 10.3174/ajnr.a5942